Ann Intern Med. 1988; 319:689-98. http://www.ncbi.nlm.nih.gov/pubmed/3045550?dopt=AbstractPlus, 45. Voltaren (diclofenac sodium enteric-coated tablets) prescribing information. Physicians’ desk reference. Biotransformation of diclofenac sodium (Voltaren) in animals and in man. 43rd ed. Eur J Clin Pharmacol. 40 rogor 40 ec products are offered for sale by suppliers on Alibaba.com A wide variety of rogor 40 ec options are available to you, There are 1 suppliers who sells rogor 40 ec on Alibaba.com, mainly located in Asia. Kramer MR, Levene C, Hershko C. Severe reversible autoimmune haemolytic anaemia and thrombocytopenia associated with diclofenac therapy. Montvale, NJ: Medical Economics Company Inc; 1993:273-4. 1986; 80(Suppl 4B):64-9. http://www.ncbi.nlm.nih.gov/pubmed/2939715?dopt=AbstractPlus, 93. Effect of diclofenac on plasma levels of immunoreactive prolactin, follicle stimulating hormone, luteinizing hormone, thyrotropin, and β-endorphin in humans. 1997; 48:626-32. http://www.ncbi.nlm.nih.gov/pubmed/9065537?dopt=AbstractPlus. Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis. 1982; 245:67-68. Psych Med. Lundstam SOA, Leissner KH, Wahlander LA et al. East Hanover, NJ; 2005 Jul. Myoclonies au cours d’un traitement par le diclofenac. Eur J Clin Pharmacol. 152. The top countries of supplier is China, from which the percentage of rogor 40 ec supply is 100% respectively. Pharmacology of diclofenac sodium. 1990; 18:104-11. http://www.ncbi.nlm.nih.gov/pubmed/2111251?dopt=AbstractPlus, 280. NSAIDs and incident Alzheimer’s disease: the Rotterdam Study. Hart FD, Huskisson EC, Answell BM. Rossi E, Ferraccioli GF, Cavalieri F et al. Curr Ther Res. 75. BMJ. In: Physicians’ desk reference. Sallmann AR. 73. * available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name, Tablets, delayed-release (enteric-coated), Diclofenac Sodium Delayed-release Tablets, Diclofenac Sodium Extended Release Tablets, Tablets, delayed-release (enteric-coated core), film-coated, 50 mg diclofenac sodium enteric-coated core, with 200 mcg of misoprostol outer layer*, Diclofenac Sodium and Misoprostol Delayed-release Tablets, 75 mg diclofenac sodium enteric-coated core, with 200 mcg of misoprostol outer layer*. 1985; 30:609-18. http://www.ncbi.nlm.nih.gov/pubmed/3909233?dopt=AbstractPlus, 37. The comparative gastric ulcerogenic activities of non-steroid anti-inflammatory drugs. Report on a long-term tolerability study of up to two years with diclofenac sodium (voltaren). J Int Med Res. Am J Med. Am J Med. 65. BMJ. AUDIENCE: Consumer, Patient, Health Professional, Pharmacy. Peripheral antialgesics: a review. Synovial fluid concentrations of diclofenac in patients with rheumatoid arthritis or osteoarthritis. 1976; 224:30-42. http://www.ncbi.nlm.nih.gov/pubmed/13749?dopt=AbstractPlus. 1988; 29:143-6. http://www.ncbi.nlm.nih.gov/pubmed/2975630?dopt=AbstractPlus, 225. 236. 3. 1988; 16:656-9. http://www.ncbi.nlm.nih.gov/pubmed/3149152?dopt=AbstractPlus, 214. 1984; 12:346-50. http://www.ncbi.nlm.nih.gov/pubmed/6394405?dopt=AbstractPlus, 136. Accessed 2016 Mar 22. http://www.fda.gov/Drugs/DrugSafety/ucm451800.htm, 501. Br J Clin Pract. Rorarius M, Miralles J, Baer GA et al. Chamouard JM, Barre J, Urien S et al. 1982; 142:165-6. http://www.ncbi.nlm.nih.gov/pubmed/7053720?dopt=AbstractPlus. 1987; 32:249-52. http://www.ncbi.nlm.nih.gov/pubmed/3595697?dopt=AbstractPlus. 1986; 80(Suppl 4B):39-42. http://www.ncbi.nlm.nih.gov/pubmed/3518431?dopt=AbstractPlus, 81. , ale rozhodnu se kolik a za kolik“., ale určím si na jak dlouho a za jakých podmínek“. 129. Be the first to write the review | Write review. Catalano MA. Bettini R, Grossi E, Rapazzini P et al. Novartis Pharmaceuticals Corporation. Müller FO, Hundt HKL, Müller DG. 1978; 15:10. Effect of topical and oral diclofenac on superficial thrombophlebitis caused by intravenous infusion. Wasner CK. Szczeklik A, Gryglewski RJ, Czerniawska-Mysik G et al. Increased mortality and cardiovascular morbidity associated with use of nonsteroidal anti-inflammatory drugs in chronic heart failure. Bavry AA, Khaliq A, Gong Y et al. N Engl J Med. Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. 1994; 343:1051-2. http://www.ncbi.nlm.nih.gov/pubmed/7909094?dopt=AbstractPlus, 270. Biotransformation of diclofenac sodium (Voltaren) in animals and in man: I. Lehtola J, Sipponen P. A gastroscopic and histological double-blind study of the effects of diclofenac sodium and naproxen on the human gastric mucosa. Plasma and synovial fluid concentrations of diclofenac sodium and its hydroxylated metabolites during once-daily administration of a 100 mg slow-release formulation. 1988; 36:482. http://www.ncbi.nlm.nih.gov/pubmed/3361048?dopt=AbstractPlus, 161. J Allergy Clin Immunol. In: Physicians’ desk reference. 1993; 19:5991. For prescription NSAIDs, FDA is requiring changes to the prescribing information to describe the risk of kidney problems in unborn babies that result in low amniotic fluid. 1988; 297:1017-21. http://www.ncbi.nlm.nih.gov/pubmed/3142593?dopt=AbstractPlus http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1834765&blobtype=pdf, 219. Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? 1980; 87:2036-40. Koch-Weser J. Nonsteroidal antiinflammatory drugs (first of two parts). Caldwell JR. Diclofenac sodium in the treatment of rheumatoid arthritis and osteoarthritis. Food and Drug Administration. 10th ed. Ciccolunghi SN, Chaudri HA, Schubiger BI et al. . 1985; 4:166-70. 1980; 28:359-66. Scand J Rheumatol. 2011; 8:e1001098. Pharmacokinetics of diclofenac sodium after intramuscular administration in combination with triamcinolone acetate. 1999; 106(Suppl 5B):37-42S. 184. Prostaglandins Other Lipid Mediators. Naika Hokan. A study to determine the clinical relevance of the pharmacokinetic interaction between aspirin and diclofenac. Abramson S, Edelson H, Kaplan H et al. 1980; 302:1179-85. http://www.ncbi.nlm.nih.gov/pubmed/6988717?dopt=AbstractPlus, 18. Al-Waili NS. Curr Ther Res. Hépatite aigue mortelle au cours d’un traitement par le diclofenac (Voltarène). are a class of medicines available by prescription and OTC. Lancet. Voltaren in co-medication. Available for Android and iOS devices. Eur J Clin Pharmacol. D’Arcy PF. Hollander D. Gastrointestinal complications of nonsteroidal anti-inflammatory drugs: prophylactic and therapeutic strategies. Chiswell RJ, Grieve AP, MacDonald IR. Agents Actions. Curr Ther Res. Siraux P. Diclofenac (Voltaren) for the treatment of osteo-arthrosis: a double-blind comparison with naproxen. Worldwide safety experience with diclofenac. Holman RM, Celinska E. Voltarol in the treatment of acute gout—a double-blind trial in general practice. Novartis Consumer Health. Scholer DW, Ku EC, Boettcher I et al. Scharf Y, Nahir M, Schapira D et al. 235. Small bowel perforation associated with an excessive dose of slow release diclofenac sodium. Clin Rheumatol. PLoS One. Rheumatic disorders. 57. 1979; 18(Suppl 2):60-8. Chan KKH, Vyas KH, Brandt KD. 1982; 25:599. http://www.ncbi.nlm.nih.gov/pubmed/7082409?dopt=AbstractPlus. 1988; 30:109-11. http://www.ncbi.nlm.nih.gov/pubmed/3054450?dopt=AbstractPlus. Gaz Med Fr. It acts … 1976; 13:292-7. Blekkenhorst GH, Cook ES, Eales L. Drug safety in porphyria. Curr Ther Res. Diclophenac sodium (Voltaren) in rheumatoid arthritis: a double-blind comparison with indomethacin and placebo. Agents Actions. Gaz Med Fr. Arthritis Rheum. Ottawa, ON, Canada; 2014 Oct 14. Thrombocytopenia associated with diclofenac therapy. Nonsteroidal anti-inflammatory drug use and Alzheimer’s disease : a case-control study in Rochester, Minnesota, 1980 through 1984. Sioufi A, Schoeller JP, Schwarzberg C et al. Faigle JW, Böttcher I, Godbillon J et al. In: Hart FD, ed. Renal syndromes associated with nonsteroidal antiinflammatory drugs. Ciprofloxacin hydrochloride: reviewers’ comments (personal observations). Kanaya T, Kanda A, Saeki T et al. Goodman and Gilman’s the pharmacological basis of therapeutics. Does the drug diclofenac have narcotics in it? COX-2 inhibitors. 1982; 21:238-42. http://www.ncbi.nlm.nih.gov/pubmed/7134745?dopt=AbstractPlus. 1986; 31:363-5. http://www.ncbi.nlm.nih.gov/pubmed/3792436?dopt=AbstractPlus, 179. 95. 1988; 18:1191-7. http://www.ncbi.nlm.nih.gov/pubmed/3266538?dopt=AbstractPlus, 178. 1983; 8:350-3. http://www.ncbi.nlm.nih.gov/pubmed/6340976?dopt=AbstractPlus, 135. Rheumatol Rehabil. BMJ. JAMA. Clive DM, Stoff JS. 59. Analysis and recommendations for agency action regarding non-steroidal anti-inflammatory drugs and cardiovascular risk. N Engl J Med. 1985; 25:455- 74. 1991; 114:735-40. http://www.ncbi.nlm.nih.gov/pubmed/2012355?dopt=AbstractPlus. Eidsaunet W, Borkje B, Larsen S et al. ), Fluid retention and edema reported.1 302 303 317 318 508, NSAIAs (selective COX-2 inhibitors, prototypical NSAIAs) may increase morbidity and mortality in patients with heart failure.500 501 504 507 508, NSAIAs may diminish cardiovascular effects of diuretics, ACE inhibitors, or angiotensin II receptor antagonists used to treat heart failure or edema.508 (See Specific Drugs under Interactions. (German; with English abstract.) Arch Intern Med. A double blind comparison of diclofenac and indomethacin in the treatment of ankylosing spondylitis. 1985; 15(Suppl 1):36-41. http://www.ncbi.nlm.nih.gov/pubmed/3936178?dopt=AbstractPlus, 21. Hori S, Shimada J, Saito A et al. Wagner J, Sulc M. Bindung von diclofenac-Na (Voltaren) an serumproteine verschiedener Spezies und Interaktionen mit anderen Pharmaka. Duncan JJ, Farr JE. 130. Increased risk of serious (sometimes fatal) cardiovascular thrombotic events (e.g., MI, stroke).1 302 303 317 318 500 502 508 Risk may occur early in treatment and may increase with duration of use.500 502 505 506 508 (See Cardiovascular Thrombotic Effects under Cautions. J Int Med Res. Effect and tolerability of diclofenac and indomethacin administered per os and as suppositories: a comparative trial. It can be applied by mixing 1-2 ml with a litre of water and spraying over the concerned plants. 1988; 32:1624-6. http://www.ncbi.nlm.nih.gov/pubmed/2855295?dopt=AbstractPlus http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=175940&blobtype=pdf. Lascar G, Grippon P, Lévy VG. Becherucci A, Bagilet D, Marenghini J et al. Oates JA, FitzGerald GA, Branch RA et al. 2001; 345:1809-17. http://www.ncbi.nlm.nih.gov/pubmed/11752357?dopt=AbstractPlus. 1975; 3:153-7. http://www.ncbi.nlm.nih.gov/pubmed/162671?dopt=AbstractPlus, 202. Am J Med. Int J Clin Pharmacol. Drug treatment: principles and practice of clinicial pharmacology and therapeutics. Lundstam S, Ivarsson L, Lindblad L. Diclofenac compared with a narcotic analgesic in the treatment of biliary pain. 1986; 13:139-42. http://www.ncbi.nlm.nih.gov/pubmed/3519020?dopt=AbstractPlus, 107. 97. The influence of food on the absorption of diclofenac after single and multiple oral doses. Isolated minimal change nephropathy associated with diclofenac. Morán M. An observer-blind comparison of diclofenac potassium, piroxicam and placebo in the treatment of ankle sprains. JAMA. ), Anaphylactoid reactions (e.g., anaphylaxis, angioedema) reported.1 302 303 317 318, Immediate medical intervention and discontinuance for anaphylaxis.1 302 303 317 318, Avoid in patients with aspirin triad (aspirin sensitivity, asthma, nasal polyps); caution in patients with asthma.1 302 303 317 318, Serious skin reactions (e.g., exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) reported; can occur without warning.1 302 303 317 318 Discontinue at first appearance of rash or any other sign of hypersensitivity (e.g., blisters, fever, pruritus).1 302 303 317 318, Do not use multiple diclofenac-containing preparations concomitantly.1 302 303 Concomitant use of diclofenac sodium 1% gel and oral NSAIAs may increase risk of adverse effects.318, Observe the usual cautions, precautions, and contraindications associated with misoprostol therapy when diclofenac is used in fixed combination with misoprostol.284, Severe, sometimes fatal, reactions including jaundice, fulminant hepatitis, liver necrosis, and hepatic failure reported rarely with diclofenac.1 302 303 317 318 323, Elevations of serum ALT or AST reported.1 302 303 317 318 323, Monitor for symptoms and/or signs suggesting liver dysfunction.1 302 303 317 318 323 Obtain serum transaminase values 4–8 weeks after initiating therapy; monitor periodically during long-term therapy.317 318 323 ALT (SGPT) is the recommended hepatic function marker for monitoring liver injury.317 318 323, Discontinue if abnormal liver function test results persist or worsen, if clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur (e.g., eosinophilia, rash).1 164 255 302 303 317 318 323, Anemia reported rarely.1 302 303 317 318 Determine hemoglobin concentration or hematocrit in patients receiving long-term therapy if signs or symptoms of anemia occur.1 248 302 303 317 318, May inhibit platelet aggregation and prolong bleeding time.3 40 41 42 43 165 166, Minimize or avoid exposure of treated areas to natural or artificial sunlight.318 Topical application of diclofenac gel formulations has resulted in early onset of ultraviolet (UV) light-related skin tumors in animal studies.318 321 The potential effects of topical diclofenac gel on skin response to UV damage in humans are not known.318, Application to nonintact skin may alter absorption and tolerability; apply only to intact skin.318, Avoid contact with the eyes and mucous membranes.318 If contact with the eyes occurs, thoroughly rinse the eyes with water or saline.318 If ocular irritation persists for >1 hour, consult a clinician.318, Avoid contact with eyes and mucous membranes.317 If contact with the eyes occurs, thoroughly rinse the eyes with water or saline.317 If ocular irritation persists for >1 hour, consult a clinician.317, Do not apply to nonintact or damaged skin.317, Patient should bathe or shower after removing one transdermal system and before applying a new system; the transdermal system should not be worn during bathing or showering.317, Store and discard transdermal systems in a manner that avoids accidental exposure or ingestion by children or pets.317, Not a substitute for corticosteroid therapy; not effective in the management of adrenal insufficiency.1 248 302 303 317 318, May mask certain signs of infection.1 302 303 317 318, Obtain CBC and chemistry profile periodically during long-term use.1 302 303 317 318, Category C.1 302 303 317 318 Avoid use in third trimester because of possible premature closure of the ductus arteriosus.1 302 303 317 318, Category X (in fixed combination with misoprostol).284 Misoprostol exhibits abortifacient activity and can cause serious fetal harm.284, Distributed into milk; 3 discontinue nursing or the drug.1 302 303 317 318, Safety and efficacy not established in children.1 302 303 317 318, Good results with oral diclofenac obtained in a limited number of children 3–16 years of age for the management of juvenile rheumatoid arthritis†.3 128 210, Oral diclofenac: Caution advised.1 302 303 Fatal adverse GI effects reported more frequently in geriatric patients than younger adults.1 302 303 317 318, Diclofenac sodium 1% gel: No substantial difference in safety and efficacy in individuals ≥65 years of age compared with younger individuals; possibility of greater sensitivity to the drug in some geriatric individuals.318, Diclofenac epolamine transdermal system: Insufficient experience in individuals ≥65 years of age to determine whether geriatric patients respond differently than younger individuals.317, Use diclofenac with caution because of age-related decreases in renal function.317 318 May be useful to monitor renal function.317 318, Metabolites eliminated principally via the kidney.1 302 303, Use with caution in patients with renal disease.1 302 303 317 318 Use not recommended in patients with advanced renal disease; close monitoring of renal function advised if used.1 248 302 303 304 317 318, Oral diclofenac: Abdominal pain or cramps,1 75 86 93 107 113 136 302 303 constipation,1 75 113 132 134 136 302 303 diarrhea,1 84 86 87 93 95 125 134 302 303 flatulence,1 302 303 GI bleeding,1 302 303 GI perforation, 1 302 303 peptic ulcer,1 302 303 vomiting, 1 302 303 dyspepsia,1 302 303 nausea,1 76 78 84 85 93 95 96 97 98 99 109 111 113 126 129 134 165 302 303 dizziness,1 102 107 113 125 129 165 302 303 headache,1 89 90 91 93 95 107 110 113 118 125 127 129 132 165 302 303 liver function test abnormalities,1 116 125 165 189 209 223 255 302 303 renal function abnormalities,1 302 303 anemia,1 302 303 prolonged bleeding time,1 302 303 pruritus,1 302 303 rash,1 302 303 tinnitus,1 302 303 edema.1 109 125 132 159 165 302 303, Diclofenac sodium 1% gel: Application site reactions (e.g., dermatitis).318, Diclofenac epolamine transdermal system: Application site reactions (e.g., pruritus, dermatitis), nausea, altered taste.317, Only minimally displaces other highly protein-bound drugs from binding sites; however, may be displaced from binding sites by other highly protein-bound drugs.51 52 59 61, Reduced BP response to ACE inhibitor1 248 302 303 317 318, Possible deterioration of renal function in individuals with renal impairment315, Reduced BP response to angiotensin II receptor antagonist315, Antacids (magnesium- or aluminum-containing), Possible bleeding complications1 302 303 317 318, Decreased peak plasma concentration and AUC of diclofenac;22 61 184 202 302 303 limited data indicate that diclofenac does not inhibit antiplatelet effect of aspirin262, Increased risk of GI ulceration and other complications1 302 303 317 318, No consistent evidence that low-dose aspirin mitigates the increased risk of serious cardiovascular events associated with NSAIAs305 317 318 502 508, Manufacturer states that concomitant use not recommended1 302 303 317 318, Possible increase in nephrotoxic effects of cyclosporine1 302 303 318, Reduced natriuretic effects1 22 179 302 303 317 318, Monitor for diuretic efficacy and renal failure1 302 303 317 318, Increased plasma lithium concentrations1 176 188 265 302 303 317 318, Monitor for lithium toxicity1 302 303 317 318, Severe, sometimes fatal toxicity associated with increased plasma methotrexate concentrations175 307, Possible increased risk of seizures183 197 198, Well absorbed following oral administration.1 3 51 52 53 57 68 189 302 303 Undergoes first-pass metabolism; only 50–60% of a dose reaches systemic circulation as unchanged drug.1 52 53 73 284 302 303, Peak plasma concentration usually attained within about 1 hour (diclofenac potassium conventional tablets), 2 hours (diclofenac sodium delayed-release tablets), or 5.25 hours (diclofenac sodium extended-release tablets).1 3 51 52 302 303 307, Absorbed into systemic circulation following topical administration as gel or transdermal system; plasma concentrations generally very low compared with oral administration.3 227 317 318, Following application of a single diclofenac epolamine transdermal system to intact skin on the upper arm, peak plasma concentrations occur in 10–20 hours.317, Following topical application of diclofenac sodium 1% gel, peak plasma concentrations occur in about 10–14 hours.318, Moderate exercise does not alter systemic absorption of topically applied diclofenac (transdermal system or 1% gel).317 318, Application of a heat patch for 15 minutes before application of the 1% gel did not affect systemic absorption.318 Not established whether application of heat following gel application affects systemic absorption.318, Single 50- or 100-mg doses of diclofenac potassium provide pain relief within 30 minutes.307, Pain relief lasts up to 8 hours following administration of single 50- or 100-mg doses of diclofenac potassium.307, Food delays time to reach peak plasma concentration but does not affect extent of absorption following administration as conventional, delayed-release, or extended-release tablets.1 302 303, Following oral administration, concentrations in synovial fluid may exceed those in plasma.1 3 62 63 64 65 66 67 68 69 302 303, Metabolized in the liver via hydroxylation and conjugation.1 3 51 52 68 70 302 303 Some metabolites may exhibit anti-inflammatory activity.1 3 22 302 303, Excreted in urine (65%) and in feces via biliary elimination (35%) as metabolites.1 3 51 55 56 70 71 302 303, Oral preparations: 1–2 hours.2 53 57 60 302 303, Diclofenac epolamine transdermal system: Approximately 12 hours.317, In geriatric patients, pharmacokinetic profile similar to that in younger adults.307, In patients with renal impairment, plasma clearance not substantially altered,1 3 208 302 303 although clearance of metabolites may be decreased.3 72, 25°C (may be exposed to 15–30°C).318 Do not freeze.318, Inhibits cyclooxygenase-1 (COX-1) and COX-2.285 286 287 288 289 290, Pharmacologic actions similar to those of other prototypical NSAIAs;1 3 20 21 22 23 24 25 26 189 302 303 317 318 exhibits anti-inflammatory, analgesic, and antipyretic activity.1 3 21 22 23 189 302 303 317 318, Importance of reading the medication guide for NSAIAs that is provided each time the drug is dispensed.1 302 303 317 318, Risk of serious cardiovascular events (e.g., MI, stroke).1 302 303 317 318 500 508, Risk of GI bleeding and ulceration.1 167 181 302 303 317 318, Risk of serious skin reactions.1 302 303 317 318 Risk of anaphylactoid and other sensitivity reactions.1 302 303 317 318, Importance of seeking immediate medical attention if signs and symptoms of a cardiovascular event (chest pain, dyspnea, weakness, slurred speech) occur.1 302 303 317 318 500 508, Importance of notifying clinician if signs and symptoms of GI ulceration or bleeding, unexplained weight gain, or edema develops.1 302 303 317 318, Importance of discontinuing diclofenac and contacting clinician if rash or other signs of hypersensitivity (blisters, fever, pruritus) develop.1 302 303 317 318 Importance of seeking immediate medical attention if an anaphylactic reaction occurs.1 302 303 317 318, Importance of discontinuing therapy and contacting clinician immediately if signs and symptoms of hepatotoxicity (nausea, anorexia, fatigue, lethargy, pruritus, jaundice, upper right quadrant tenderness, flu-like symptoms) occur.1 302 303 317 318, Risk of heart failure or edema; importance of reporting dyspnea, unexplained weight gain, or edema.508, Importance of warning patients to keep diclofenac transdermal system out of the reach of children and pets and to safely dispose of used units.317 Importance of properly disposing of dosing cards used to apply diclofenac gel.318, Importance of adhering to instructions for administration of topical gel or transdermal system.317 318, Importance of avoiding or limiting exposure of skin treated with diclofenac gel to natural or artificial sunlight.318, Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1 302 303 317 318 Importance of avoiding diclofenac in late pregnancy (third trimester).1 302 303 317 318, Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.1 302 303 317 318, Importance of informing patients of other important precautionary information.1 302 303 317 318 (See Cautions.). Am J Med. Circulation. 1984; 8:881- 2. http://www.ncbi.nlm.nih.gov/pubmed/6526249?dopt=AbstractPlus, 215. Alcalay M, Thomas P, Reboux JF et al. Rheumatol Rehabil. Am J Sports Med. N Engl J Med. Effect of nonsteroidal anti-inflammatory drugs on the renal excretion of uric acid. 1989; 19:3-4. East Hanover, NJ; 2016 May. Diclofenac. Weisman MH. Invest Ophthalmol. 1981; 29:183-92. 1980; 19:193-8. http://www.ncbi.nlm.nih.gov/pubmed/6997973?dopt=AbstractPlus. 1975; 24:641-3. http://www.ncbi.nlm.nih.gov/pubmed/804905?dopt=AbstractPlus, 27. Diclofenac binding to albumin and lipoproteins in human serum. The differential susceptibility of prostaglandin endoperoxide H synthases-1 and -2 to nonsteroidal anti-inflammatory drugs: aspirin derivatives as selective inhibitors. Am J Med. 1999; 94:504-8. http://www.ncbi.nlm.nih.gov/pubmed/10511349?dopt=AbstractPlus, 292. Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment. Am J Med. Isolation and identification of principal metabolites. Présence du diclofénac dans le plasma et le liquide synovial au cours de diverses affections rhumatismales. Polman HA, Huijbers WAR, Augusteijn R. The use of diclofenac sodium (Voltaren) suppositories as an antipyretic in children with fever due to acute infections: a double-blind, between-patient, placebo- controlled study. Diclofenac increases beta-endorphin plasma concentrations. 2001; 345:1515-21. http://www.ncbi.nlm.nih.gov/pubmed/11794217?dopt=AbstractPlus. Ibuprofen-induced meningitis in systemic lupus erythematosus. 1980; 18:415-8. http://www.ncbi.nlm.nih.gov/pubmed/7439264?dopt=AbstractPlus. Diclofenac and pirprofen modify pituitary and hypothalamic beta-endorphin concentrations. BMJ. Yasunaga K. [Effect of N-(2,6-dichlorophenyl)- o-aminophenylacetic acid (GP 45 840) on blood platelets, coagulation and fibrinolysis.] 1986; 292:1050. http://www.ncbi.nlm.nih.gov/pubmed/20742631?dopt=AbstractPlus http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=1340115&blobtype=pdf, 163. 241. The advent of highly selective inhibitors of cyclooxygenase—a review. 1986; 80(Suppl 4B):70-80. Curr Ther Res. BMJ. Curr Ther Res. J Rheumatol. 1984; 27:232-55. http://www.ncbi.nlm.nih.gov/pubmed/6368185?dopt=AbstractPlus, 150. West Point, PA; 1985 Oct. 191. Am J Med. 1994; 96:274-81. http://www.ncbi.nlm.nih.gov/pubmed/8154516?dopt=AbstractPlus, 271. Select one or more newsletters to continue. 157. Mandell B, Shen HS, Hepburn B. A multicentre trial of Voltaren in the treatment of rheumatoid arthritis. Thérapie. 275. Absorption and effect of diclofenac-sodium after surgical removal of a lower wisdom tooth. ), 500. Chicago: American Medical Association; 1983:107-38. 85. 300. 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